Barca will again be without the services of Ousmane Dembele due to a long-term hamstring problem, while Clement Lenglet is suspended because of the booking that he picked up against Sociedad last time out.
Lenglet’s spot at the back is expected to be taken by Samuel Umtiti, while Sergi Roberto should get the nod at right-back due to the uncertainty surrounding Nelson Semedo’s involvement.
Semedo trained alone on Thursday after reportedly breaching rules by attending a birthday party with 20 people. The Portuguese is expected to undergo another coronavirus test before his involvement is confirmed, but Roberto is the favourite to feature on the right side of the back four.
Elsewhere, Lionel Messi has overcome an injury scare and will start in the final third, while the lockdown period has allowed first-choice centre-forward Luis Suarez the chance to recover from a knee operation.
Antoine Griezmann should join Messi and Suarez in a three-man attack, but Setien has a big decision to make when it comes to who starts alongside Sergio Busquetsand Frenkie de Jong in midfield.
Arthur and Ivan Rakitic are both in contention to make the XI, but Arturo Vidalis being tipped to get the nod despite being strongly linked with a move away from Camp Nou over the last few weeks.
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